Saturday, 6 April 2013

NMR LipoProfile - LDL particle numbers

NMR LipoProfile



What is the NMR LipoProfile®

The NMR LipoProfile® test is an advanced cardiovascular diagnostic test that uses nuclear magnetic resonance (NMR) spectroscopy to uniquely provide rapid, simultaneous and direct measurement of LDL particle number and size of LDL particles, as well as direct measurement of HDL and VLDL subclasses.  This detailed lipoprotein particle information allows clinicians to make more effective individualized treatment decisions than previously possible based on standard lipid panel testing. The atherosclerotic culprit is LDL particle number, not LDL cholesterol.

Why should I use the NMR LipoProfile® test?

You should use the NMR LipoProfile® test because it provides a more accurate picture of cardiovascular (CVD) risk than the standard lipid panel. Each year, heart attacks kill more than 8 times as many women than breast cancer and 15 times as many men than prostate cancer. According to a major study, 50% of the people who suffered a heart attack had normal cholesterol levels. If your cholesterol is normal, being lowered by treatments like diet, exercise, or medication; or you have any of the conditions listed below, the NMR LipoProfle test may be right for you:
  • Diabetes
  • Previous heart attack
  • Family history of heart attack
  • High blood pressure
  • Overweight/Obesity
  • Cardiometabolic risk
  • Metabolic syndrome
  • Low HDL (dyslipidemia)
  • High triglycerides
For more information:
Understanding the NMR LipoProfile


Retail price of $167



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A Raleigh-based company has developed a new blood test that can more accurately predict a person's risk of heart disease.

Cholesterol tests are the standard method to identify risk, but half of all people who have heart attacks had normal cholesterol.

The American Diabetes Association and the American College of Cardiology support a new type of blood test that they say more accurately measures risk.

The NMR Lipoprofile uses nuclear magnetic resonance to count LDL – or low-density lipoprotein particles – which carry cholesterol throughout the body via the blood stream.

"It's the LDL particle number that is the driving force for the coronary artery and cerebral vascular disease and the cause of stroke and heart attack," cardiologist Dr. Seth Baum said.

The most commonly-used blood test, called a lipid panel, measure the amount of cholesterol carried by LDL particles. However, research shows it is the number of lipoprotein particles – not the amount of cholesterol – present in the blood that leads to plaque build-up on artery walls.

"By upgrading their lipid tests to the NMR Lipoprofile, doctors are in a much better position to identify their patients' risk," Baum said.

Doctors can then prescribe ways to manage the risk, including statin therapy or combination therapy. The new test will most benefit patients with risk factors for heart disease, such as obesity, insulin resistance or high blood pressure, Baum said.

The NMR Lipoprofile was developed by LipoScience, which has its headquarters in Raleigh.